放射性核素磷近距离治疗小儿皮肤血管瘤的近期疗效

Short term efficacy of brachytherapy with radioactive 32P for infant skin hemangioma.

目的:探讨放射性核素磷(32P)近距离治疗小儿皮肤血管瘤的临床疗效及辐射损伤。方法:173例小儿皮肤血管瘤患儿随机分为治疗组92例,对照组81例,采用32P敷贴器以不同的剂量、不同的治疗疗程行近距离治疗,观察其临床疗效及辐射损伤。结果:32P敷贴器放射性面密度的估算值与实测值误差为5.4%±0.9%;治疗组和对照组患者经32P治疗1个～4个疗程后病灶总治愈率均为100%;两组病例治疗后均出现皮肤辐射损伤,且与皮肤血管瘤病变的面积密切相关,治疗组的辐射损伤比对照组轻(P<0.05),皮肤血管瘤病变较厚者疗效较低,增加治疗疗程可提高疗效(P<0.05)。结论:多疗程、低剂量的32P近距离治疗小儿皮肤血管瘤可取得更佳的临床治疗效果。

Objectives:To study the short term efficacy and radiation injury of brachytherapy with radioactive 32P for infant skin hemangioma. Methods:173 infant patients were treated with interstitial radioactive 32P brachytherapy of different dosages and durations,with 92 patients in treatment group and 81 patients in control group. Results:The calculate measure error of radioactivity density of 32P applicator was less than (5.4±0.9) %. There was no significant difference in curative rate between two groups. Skin radiation injury was more severe in control group (P< 0.05) than that in treatment group. It was closely correlated with the size of skin hemangioma (P< 0.05). The curative effect decreased as lesion depth increased (P< 0.05). Conclusion:Excellent control of infant skin hemangioma can be achieved by using interstitial brachytherapy with low but frequent dose of radioactive 32P.