胺碘酮与起搏器联合治疗病窦综合征并阵发性心房颤动的观察

Effects of Amiodarone on P aroxysmal Atrial Fibrillation in The Patients With Pacemaker.

观察胺碘酮与起搏器联合治疗病窦综合征并阵发性心房颤动 (简称房颤 )有效性及安全性。 52例慢 快综合征患者 ,起搏器治疗后仍有阵发性房颤 (经心电图和动态心电图证实 ) ,在停用其他抗心律失常药物至少 5个半衰期后 ,按标准方案给予胺碘酮治疗 :负荷量 0 .2g,3次 /天 ,7天 ;继以 0 .2g,2次 /天 ,7天 ;维持量为 0 .2g ,1次 /天 ,连续服用 3个月。根据临床症状和动态心电图评价疗效及安全性。结果 :观察 9.6± 1 3 .5(2 .7～ 2 8)个月 ,总有效率为 69.2 % ,动态心电图自身心律所占时间 ,治疗前为 7.6± 3 .2 (5 .5～ 1 2 .5)h/d ,治疗后为 3 .4± 2 .6(0～ 7.2 )h/d(P <0 .0 1 ) ;在随访期间有 2例促甲状腺素轻度升高 ,经调整剂量后恢复正常 ;1例皮肤搔痒 ,经减量后症状消失。结论

To evaluate the effects and safty of amiodarone combination with pacemaker on paroxysmal atrial fibrillation(AF) accompanying with bradycardia-tachycardi a syndrome,52 patients with AF,which were treated by pacemaker because of bradyc ardia,were orally given amiodarone according to standard regime.The effectivenes s was evaluated by clinical symptom and Holter monitoring.Results:Within 9.6±13 .5(2.7～28) months follow-up,the total effective rate of amiodarone was 69.2%; significant side effects weren′t found.Conclusion:It is effective and safe for amiodarone combination with pacemaker to treat paroxysmal AF in patients with b radycardia-tachycardia syndrome.