海带素(FGS)对高胆固醇血症小鼠血清胆固醇的调节作用

Study on the serum cholesterol regulation of FGS from Lamina- ria japonica Aresch

以实验型高胆固醇血症小鼠为模型,每天用250、750及1500mg·kg-1的海带素（FGS）灌胃高胆固醇血症小鼠,分别在第10、20、30和40天测定血清胆固醇含量,结果表明:第40天Ⅰ、Ⅱ、Ⅲ实验组的TC比对照组分别降低37.6、54.2、66.2mg·dL-1,LDL-C比对照组分别降低47.6、86.6、94.4mg·dL-1,HDL-C比对照组分别升高16.1、38.2、36.7mg·dL-1,说明海带素能有效地调节血清胆固醇水平。

The hypercholesterolemia model was established by feeding mice on hypercholester-ol diet. FGS was administered to the hypercholesterolemia mice at the dose of 250,750 and 1500mg · kg-1 ·d-1, respectively. On the 10,20,30 and 40th day, the serum cholesterol was determined. The results were as follows: 40th day the concentration of TC(Ⅰ,Ⅱ,Ⅲ) was 37. 6,54. 2 and 66. 2mg ·dL-1 lower than that of the control group; and the cocentration of LDL-C was 47. 6,86. 6 and 94. 4mg ·dL-1 lower than that of the control group; while the concentration of HDL-C was 16. 1,38. 2 and 36. 7mg·dL-1 higher than that of the control group. It was proved that FGS was an effective serum cholesterol regulator.