紫红獐牙菜提取物对小鼠骨髓嗜多染红细胞微核率的影响

THE EFFECT OF S. PUNICEA HEMSL ON THE MICRONUCLEUS IN PCE OF THE MOUSE BONE MARROW

本文以小鼠骨髓嗜多染红细胞微核率(PCEMNR)为指标,测定了抗病毒性肝炎新药紫红獐牙莱的提取物对哺乳动物遗传物质的诱变作用。结果表明,按该药临床人体使用量的5倍、20倍和100倍的剂量灌胃处理小鼠所诱发的骨髓PCEMNR与阴性对照(生理盐水处理组)相比均无显著性差异(P>0.05),初步说明紫红獐牙菜提取物对哺乳动物的遗传物质可能不具有损伤效应。

The micronuclei rate of polychromatic erythrocytes of mouse bone marrow (PCEMNR) was used as an index to study the effect of S. punicea Hemsl, a new anti-hepatitis drug, on genetic material of mammal. The mice took the drug by mouth with the dose (g/kg) of 5 times, 20 times and 100 times as much as human' s dose in clinical use. The result showed that none of the PCEMNRs of three experimental groups was significantly higher than that of control group (P>0. 05). These findings suggested that the extract of S. punicea Hemsl had no damage to the genetic material of mammal.