标准剂量及大剂量异环磷酰胺单用或联合应用治疗肉瘤

EFOSFAMIDE IN SARCOMAS, ALORE & IN COMBINATION AT STANDARD & HIGH DOSE SCHEDLES

本文介绍美国Dana Farber癌症研究所应用异环磷酰胺治疗肉瘤的经验。除试用标准剂量及大剂量异环磷酰胺治疗外,作者报告了MAID联合化疗方案(Mesna,Adriamycin Ifosfa-mide,DTIC)105例,11例获CR(10％)48例PR(47％),总缓解率57％。加用GM—CSF有骨髓保护作用。以大剂量异环磷酰胺、卡铂、VP—16加自身骨髓移植组疗效最好。

144 sarcoma patients who had failed at least one prior chemotherapy regimen were treated with doses of ifosfamide ranging between 8 to 18gm/ M2 divided over Four days with mesna uroprotetion. The response rate was 12-23% ; 105 patients received continuous infusion MAID, CR was 10% and PR rate was 47%, the median survival was 16 months, myelosuppression was dose limiting, nonhematologic toxicity consisisted of N/ V, severe mucositis, macroscopic hematuria, renal tubular acidosis, renal failure and CNS toxicity; 16 patients received 32μg/ kg/day of GM- Csf before and immediately after cycle 1 of MAID che mo therapy, myelo- protect activity was observed in leukopenic patients: High doseifosfammde, carboplatin and Vp-16 with auto marrow support has optimal therapentic effecacyfor sarcomas.