电子感应加速器和^(60)Co治疗鼻咽癌疗效的比较——100例前瞻性随机研究

COMPARISON OF THE EFFECTIVENESS OF BETATRON AND ^(60)Co TREATMENT FOR NASOPHARYNGEAL CARCINOMA -PROSPECTIVE STUDIES ON 100 CASES

作者对本院1981年下半年收治的100例鼻咽癌进行前瞻性研究,随机将病例分为高能电子线组和~60Co组,两组在治疗方法、时间剂量相同的情况下,比较其疗效,后遗症和死亡原因。结果表明:两组3、5、8年生存率分别为67.5％,50％,40％和63％,48.3％,38.3％。无明显差异。远期后遗症包括皮肤纤维化,张口受限在高能电子线组较明显。两组死亡原因均以局部复发较多,比远处转移致死的发生率为高。

The present study summarized 100 cases of nasopharyngeal carcinomatreated in our hospital in the second half year of 1981. These patients were divided, according to prospective randomization, into two groups- 40 treated by high-energy electron beam betatron and the other 60 treated by 60Co. The two groups were similar with srespect of the ages, sexes, stages, irradiation fiels, dose time, factors, eel In order to compare the results, late sequelae and the causes of death were analyzed. The 3, 5, 8-year survival rates in the betatron group and in the 60Co group were 67.5%, 50% , 40% and 63% , 48.3% , 38.3% , respectively. There was no nstatistically significant difference between the survival rates of the two groupa The survival rates of nasopharyngeal carcinoma patients treated by betatron were similar to those reported by other hospitals in this country. Among the late sequelae, the fibrosis of skin and the. difficulty in opening mouth were more obvious in high-energy electron beam group than those in the 60Co group. The principal cause of death of both groups was the recurrence of the pre-existed (including nasopharynx, cervical lymph node, and skull base), which resulted in higher incidence of death than the distant metastasis.