简易的血清唾液酸动态监测在肝胆胰癌诊断中价值的初探

THE VALUE OF SIMPLE DYNAMIC DETERMINATION OF PLASMA SIALIC ACID IN THE DIAGNOSIS OF CANCERS OF LIVER, BILIARY TRACT AND PANCREAS

本文采用一种新的简易血清唾液酸检测法——F—8836化学比色法对肝癌67例,胆囊癌7例、胰头癌4例,急慢性肝炎72例、重症肝炎28例、肝硬化44例进行检测,并对癌症组以AFP作对照观察。本法检测肝癌阳性率86.5％,用AFP检测阳性率为64.2％(二者相比,P<0.001)。11例胆胰癌,用本法检测全部为阳性,而用AFP检测均为阴性。说明本法可作为诊断肝癌的一种新指标。通过对肝癌、重症肝炎、肝硬化、急慢性肝炎连续动态监测可提高肝癌诊断的阳性率(达到95.5％),并排除假阳性或假阴性。吸光度与病情严重程度呈正比;与疗效成反比,有利于观察疗效、判断预后和转归。

with the F-8836 cotorimetry.a newly created simple method, the plasmasialic acid level of 67 cases of hepatocarcinoma, 7cases of cancer of biliary tract, 4Cases cancer of the head of pancreas, 72 cases of acute and chronic hepatitis, 28 cases of sev- ere hepatitis, 44 cases of hepattocirrhosis was determined. The α-fetoprotein (AFP) le-vls were also measured in cancer patients as well as in control with this method, the positive detectble rate for sialic acid in liver cancer patients was 86.5 percent.while that forAFPwas64.2 percent. The difference was statistically sigmnificant(P<0.001).The F-8836 absorbances in cases of cancers of biliary tract and pancreas cancer were all positive, whfle the values of AFP in these cases were completely negative. The results showed that F-8836 colorimetry might be a sensitive method for the early diagnosis of liver cancer. The dynamic determination of sialic acid level in cancers, severe hepatitis, hepatoci-rrhosis, acute and chronic hepatitis might raise the positive detectable rate of liver cancer to 95.5 percent.it could exclude false positive and or negative reaction, which benefited the therapeutic evaluation and the judgment of prognosis.