二甲基肼诱发小鼠结肠癌过程中凋谢的研究

STUDY OF APOPTOSIS IN CARCINOGENESIS OF DMH- INDUCED COLON CARCIONOMAS IN MICE

本研究选用一二甲基肼(DMH)诱发昆明种小鼠结肠癌实验模型,观察到化学诱癌过程中凋谢值渐升高。单纯增生的结肠隐窝凋谢值明显高于组织学正常者;异型增生的结肠隐窝凋谢值又显著高于单纯增生的凋谢值;而结肠腺癌的凋谢值稍低于异型增生时的凋谢值。很可能,凋谢作为内部调节机制,使受致癌物损伤的隐窝底部细胞在发生处死亡(原位死亡)。这个观察结果提示凋谢对癌发生起重要作用。

A model of l,2-dimethylhydrazine(DMH)induced colon neoplasms inmice was used to investigate the apoptosis in carcinogenesis. A progerssively increased frequency of apoptosis was observed in the process of carcinogenesis of colon neoplasms. The numbers of apoptosis in hyperplastic crypts were higher than in normal crypts.and those in dysplastic crypts were obviously higher than in hyperplasia, the lowest number of apoptosis was observed in adenocarcinomas.Maybe, apoptosis in carcinogenesis is a control mechanism in orgomism.by which the cell injured by carcinogens were eliminated firstly in the base of crypts. This study suggest that apoptosis may play a significant role in the process of chemical carcinogenesis of colon.