单克隆抗体SC13A的识别抗原在乳腺癌中的表达及其意义

EXPRESSION AND ITS SIGNIFICANCE OF THE ANTIGENS RECOGNIZED BY MAb SCI3A IN BREAST MASSES

本文用PAP免疫组化法,对13种不同组织学类型157例乳腺肿物组织活检标本中的单克隆抗体SC13A所识别的抗原表达作了检测分析。结果该抗体的对应抗原在8种84例乳腺癌中表达的阳性率为89.3％,其中强阳性率占65.5％,表明此抗原在乳腺癌中的表达水平较高,这对其进一步的有关研究将是一种有用的标志物。此抗体在与73例的乳腺增生性病变的反应中16例(21.9％)呈阳性结合。这可能与这类病变中存在着与乳腺癌相同的抗原物质有关。提示其对乳腺癌的发生可能提供了一定的物质基础。

Expression of the antigens recognized by MAb SC 13A in 157 breast mass specimens from patients were studied by immunohistochemical technique. 75 of 84 (89.3% ) breast cancers specimens were stained by the MAb, and more than half of the stained tumor tissues were observed in the SC 13A binding of 46 (54.8%) cases. This association has been confirmed in our series and extended to show, for the first time, that the binding of the SC 13A antigen was correlated with breast cancer. Some weak re activities with the MAb were also seen in 21.9% (16 of 73 ) of benign breast hyperplastic disease. It may relate to the antigen expression in the benign diseases. The findings indicated that detection of this antigen may provide a clinically useful methed for the characteristics of the breast cancer.