The Analysis of Pedigree GZ (Guangzhou) . 1 with Primary Open Angle Glaucoma

Purpose:To analyze the hereditary modality of primary open-angle glaucoma in China.Methds:The genetic form of Pedigree GZ.1was analyzed using Mandalian hereditary rules.Results:PedigreeGZ.1 had following characteristics:1)The pedigree had four gene-rations,and there existed POAG patients in each generation;2)Each patient had a parent withPOAG.Ifthparents didn't suffer from the disease,their children would not.3)The incidence of POAG in the relatives of the patients was1/2,In addition,The age of onset,intraocular pressure,fundus and prognosis was different from each other in the patients.Conclusions:1)Pedigree GZ.1 is inherited as an autosomal dominant trait.2)There exists individual differences of clinical manifestations in POAG patients,Eye Science2000;16:53-55.

Purpose: To analyze the hereditary modality of primary open-angle glaucoma in China. Methods: The genetic form of Pedigree GZ. 1 was analyzed using Mandalian hereditary rules. Results: Pedigree GZ. 1 had following characteristics: 1) The pedigree had four generations, and there existed POAG patients in each generation; 2) Each patient had a parent with POAG. If the parents didn't suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1/2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients. Conclusions: 1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients. Eye Science 2000; 16: 53 - 55.