香菇多糖、银耳多糖对荷瘤小鼠的免疫调节作用

The immunoloregulation of mushroom polysaccharides and tremella polysaccharides for mouse loading tumor

目的 探讨复合多糖对S180荷瘤小鼠免疫功能的影响。方法 (1)模型 :S180 荷瘤小鼠动物模型 ;(2)免疫检测方法 :溶血素测定 ,T淋巴细胞转化功能测定 ,腹腔巨噬细胞吞噬功能测定。(3)受试药物及给药方法 :复合多糖口服。结果 复合多糖以0.75g/kg剂量灌胃荷瘤小鼠 ,可明显提高血清溶血素(p<0.05)和T淋巴细胞转化功能(p<0.05) ,表明该制剂可明显提高荷瘤小鼠的体液和细胞免疫功能。同时以1.5g/kg和0.75g/kg剂量可明显提高荷瘤小鼠的腹腔吞噬细胞功能(p<0.05～0.01) ,表明该制剂对非特异性免疫有明显的促进作用。结论 复合多糖对肿瘤机体免疫功能有明显的促进作用。

Objective To evaluate the effect of compound polysaccharide on immunological function of mouse. Method Build animal model of S180 mouse loading tumor, take orally compound polysaccharide, assay hemolysin, T lymphocyte conversion function, abdominal cavity macrophage function. Results Compound polysaccharide givened by gavage for mouse loading tumor in a dose of 0.75g/kg could significantly increase serum hemolysin and T lymphocyte conversion function(p<0.05). The dose of 1.5g/kg和0.75g/kg could enhance abdominal cavity macrophage function(p<0.01). Conclusion Compound polysaccharide can significantly improve immunological function.