血液灌流对急性中、重度毒鼠强中毒的疗效评价

Clinical evaluation of therapy with hemoperfusion in moderate to severe tetramine poisoned patients

目的 通过 6 4例中、重度毒鼠强中毒病例的治疗 ,评价血液灌流在治疗毒鼠强中毒的应用价值。方法 对6 4例中、重度中毒病人于血液灌流前后及清醒、抽搐停止时的血毒浓度进行测定 ,血液灌流的间隔时间为 2 4h。并对入院时、第 3天、第 7天的生化酶学指标进行测定 ,分析其之间的相关性。结果 ①血毒浓度与临床症状 :血毒浓度越高 ,其临床症状越明显 ;②血液灌流疗效 :血液灌流能有效地降低血毒浓度 ,迅速改善临床症状 ,对于毒鼠强中毒的疗效显著 ,一般经 2～ 4次灌流后即可达治疗目的。③酶学指标变化 :酶学水平与血毒浓度密切相关 ,随着血毒浓度下降 ,酶学指标则迅速下降 ,接近正常。结论 血液灌流是清除血中毒鼠强的好方法。

Objective To estimate the use value of hemoperfusion for the treatment of acute moderate to severe tetramine poisoning.Methods The acute moderate to severe tetramine poisoned patients,according to their clinical features and intoxication,such as consciousness,seizures,underwent two to four sessions of hemoperfusion,each utilizing a fresh cartriadge,with one session twenty-four hours following the other.Blood samples were taken for the determination of the poison and enzymes concentration at various times respectively.Results ①The more the tetramine level of the blood was high,the more the patients clinical features was clear.②The hemoperfusion was an effective treatment method for the patient with acute tetramine poisoning.The poisoned patients were completely recovered after the method was performed two to four times.③There were a positive relationship between the poison level and the changes of enzymes in blood.Conclusion Hemoperfusion is an effective treatment method for eliminating tetramine in the blood of poisoning patients.