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骨形成蛋白-2(BMP-2)与雌激素敏感性的人类乳腺癌的关系 被引量：5

The Relationship Between BMP-2and Estrogen-dependent Human Breast Cancer
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摘要 目的:研究BMP-2(BoneMorphogeneticProtein-2,骨形成蛋白-2)在乳腺癌细胞系中的表达,探讨其对乳腺癌细胞的作用机制,评估其在乳腺癌基因治疗上的作用。方法:采用分子生物学方法(MolecularBiology)检测6种人类乳腺癌细胞系中BMP-2的表达,并分析对乳腺癌细胞生长的影响及其与治疗的关系。结果:BMP-2在所有人类乳腺癌细胞系中表达,其抑制乳腺癌细胞的生长,主要抑制于细胞周期的G1期,其抑制作用与p21蛋白的诱导有关。结论:BMP-2是对雌激素敏感的人类乳腺癌细胞的强有力抑制剂,这有可能成为在分子水平上治疗乳腺癌的新方法。 Abtract Objective:To study the expression and explore the mechanism of BMP-2in breast cancer cell lines,and evaluate the effect of BMP-2in the patients of breast cancer on gene level.Methods:Expression of BMP-2in6different kind of breast cancer cell lines was determined by the methods of molecular biology.Analyze the relationship between BMP-2and the growth of breast cancer cell.Results:BMP-2is expressed in human breast cancer cell lines and it inhibits the proliferation of estrogen-dependent breast cancer cell lines,which main in G1phase of cell cycle.BMP-2induces P21mRNA and protein levels in human breast cancer cell.Conclusion:BMP-2is a potent inhibitor of estrogen-sensitive breast cancer cell proliferation and BMP-2might be used as one of the new methods of cure in patients with breast cancer on molecular.
作者 袁霞 刘国津
机构地区 吉林大学第一医院胸外科 锦州医学院附属第一医院肿瘤科
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2002年第10期694-697,共4页 Chinese Journal of Clinical Oncology
基金 CIDA(加拿大国际发展署)项目资助
关键词 骨形成蛋白-2 雌激素 敏感性 乳腺癌 P21 治疗 Breast cancer Gene BMP-2p21Cure
分类号 R737.9 [医药卫生—肿瘤]
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参考文献11

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同被引文献30

  • 1吴凯南,孔令泉.乳腺癌骨转移若干影响因素的分析[J].中国肿瘤临床,2005,32(24):1396-1399. 被引量：8
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  • 9Sneddon JB,Zhen HH,Montgomery K,et al.Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation[J].Proc Natl Acad Sci USA,2006,103(40):14842-14847.
  • 10Helms MW,Packeisen J,August C,et al.First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer[J].J Pathol,2005,206(3):366-376.

引证文献5

二级引证文献6

中国肿瘤临床
2002年 第10期

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