失血性休克大鼠肠淋巴管压力的变化

Changes of Intestinal Lymph Pressure During Hemorrhagic Shock in Rat

目的 :探讨肠淋巴循环在失血性休克发生、发展和转归中的作用。方法 :应用肠淋巴管插管术 ,观察大鼠休克及补液过程中肠淋巴管压力的变化。结果 :休克初期 ,组间及组内的肠淋巴管压力均无显著性变化 (P >0 .0 5) ,休克期肠淋巴管压力比休克前及对照组显著降低 (P<0 .0 5～ 0 .0 1) ,回输血液及生理盐水 ,肠淋巴管压力迅速恢复且急骤升高 ,自补液 10min起 ,肠淋巴管压力明显高于实验前和对照组 (P <0 .0 5～ 0 .0 1)。血压虽有回升趋势但未完全恢复到休克前水平。停止输液后 ,肠淋巴管压力虽有所降低但仍高于实验前 (P <0 .0 5～ 0 .0 1) ,实验组输液后期淋巴管压力和血压之间呈直线相关 (r =0 .978,P <0 .0 1,y =0 .2 0 6x)。 结论

In order to explore the effect of intestinal lymph circulation on the development and outcome of hemorrhagic shock.Method: The intestinal lymph duct was cannulated by a bettered Bollman method for measuring intestinal lymph pressure.Results: The intestinal lymph pressure were lower obviously than that of pre shock and control group( P<0.05～0.01 ).When the withdrown blood and the saline solution were retransfused,the lymph pressure rose signficantly compared with pre shock and control group,and there was a signficant linear correlation between intestinal lymph pressure and blood pressure early stage on after retransfusion( r=0.978,P<0.01 ,y= 0.206 x).Conclusion: The present results suggest that intestinal lymph circulation plays an important role in the development and outcome of shock.