雌激素受体基因多态性与脑梗死关系的研究

Study on the association of estrogen receptor gene polymorphism and cerebral infarction

目的 探讨雌激素受体 (estrogenreceptor,ER)基因PvuⅡ酶切多态性在北京地区汉族人群中与脑梗死的相关性。方法 通过 2 36例脑梗死患者及 2 6 2例非脑血管病对照的临床及流行病学资料以及采用PCR RFLP方法进行的基因型分析 ,对ER基因PvuⅡ酶切多态性与脑梗死做相关分析。结果 采用多元Logistic回归模型经混杂因素调整后 ,结果 :(1)ER基因Pp基因型与脑梗死显著相关 (OR 1.91;95 %CI 1.19～ 3.0 7;P =0 .0 0 8) ;(2 )ER基因PvuⅡ酶切多态性分别与高血压、糖尿病、高脂血症对脑梗死发病的影响存在明显协同作用。结论 所研究人群中 ,ER基因PvuⅡ酶切多态性与脑梗死显著相关。

Objective To investigate the association of estrogen receptor (ER) gene PvuⅡ polymorphism with cerebral infarction in Beijing Hans.Methods In the case control study,the population's medical and epidemiological data were collected.Using PCR RFLP,genotyping was performed in 236 patients with cerebral infarction and 262 controls without cerebrovascular disease.Results After adjustment for major confounders including age,education,sex,drinking,smoking,diabetes mellitus,hypertension,coronary artery disease and hyperlipoidemia,multiple logistic regression analysis showed that:(1)Compared with PP genotype,Pp genotype could increase the risk of cerebral infarction significantly ( OR ,1.91;95% CI ,1.19～3.07; P =0.008).(2)The positive interaction between the PvuⅡ genotypes and the presence of hypertension or diabetes or hyperlipoidemia could increase the risk of cerebral infarction significantly.Conclusions In this studied population,ER gene PvuⅡ polymorphism was in association with cerebral infarction.