老年单纯收缩期高血压的病因探讨——病例对照研究

A Study on Etiological Factors of Isolated Systolic Hypertension in the Elderly——A Case-Control Study

在现况调查的基础上,对94例老年单纯收缩期高血压进行了1∶1的病例对照研究。单因素分析表明:吸烟、精神创伤、高血压家族史、体重指数与老年单纯收缩期高血压显著相关,其他因素与该病关系不显著(P>0.05)。在a=0.2时的多因素条件Logistic回归分析揭示:吸烟、高血压家族史、精神创伤、血糖和TG进入方程,前三者有显著意义(P<0.05)。进一步分析发现吸烟与ISHE间存在剂量—效应关系;亲属中有高血压病史愈多,患ISHE的危险性愈大,有一级亲属家族史者患ISHE的危险性是无家族史者的8.34倍,是有配偶家族史者的6.28倍。

Basing on the prevalently survey, we conducted a case—control study on isolated systolic hypertension of elderly (ISHE) for 94 cases. Mono—variate analysis showed that smoking, mental accident, family history, body weight index correlated significantly with ISHE (P<0.05), but the other didn't (P>0.05). The data were analysed by multi—conditional logistic regression model. It turned out that smoking, family history, mental accident, blood sugar and TG got into the model, and correlations with smoking, family history and mental accident were significant (P<0.05). Futher analysis found that dose—effect relation existed between smoking and ISHE. The more members of family history of hypertension, the more the risk of ISHE. The frequency of those with first class relative family history suffered from ISHE was 8.34 times as those without family history and was 6.28 times as those with spous family history.