慢性阻塞性肺病的低氧血症与血浆睾酮的关系

A Study on the Relation Between Plasma Testosterone Level and Hypoxemia of Chronic Obstructive Pulmonary Disease

对66例长期慢性缺氧的慢性阻塞性肺病(COPD)患者和20例正常对照人群进行了血气分析与血浆睾酮值的检查,结果发现:(1)长期慢性缺氧的COPD患者的血浆睾酮值显著地低于正常对照组;随着病程的延长,其血浆睾酮值逐渐下降。(2)半数以上的COPD患者PaO_2低于10.7kPa;血浆睾酮值与PaO_2间有显著的正相关。PaO_2大于10.7kPa患者的血浆睾酮值显著地高于PaO_2小于10.7kPa者。本研究揭示了COPD低氧血症与血浆睾酮之间的关系,为研究由低氧血症引起的病理变化提供了依据。

Plasma testosterone, PaO_2,PaCO_2 etc were measured in 66 cases of chronic obstructive pulmonary disease (COPD) with long—time chronic oxygen deficiency and 20 normal controls. The plasma testosterone of the cases was significantly lower than that of the controls. Futhermore, it decreased gradually with the progress of disease. More than half of the cases'PaCO_2 were below 10.7 kPa and there was significant positive correlation between plasma testoterone and PaCO_2. In addition, the plasma testosterone of the cases whose PaO_2over 10. 7 kPa was significantly higher than those of below 10.7 kPa,The results revealed the relation between sex hormone (plasma testosterone) and hypoxemia of COPD, and could provide valuable information for the further studies on the pathophysiological changes of hypoxemia.