慢性阻塞性肺部疾患特异性转移因子的研制及疗效观察

RESEARCH AND PRODUCTION OF SPECIFIC TRANSFER FACTOR USED FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ITS CLINICAL EFFECT

正常人源转移因子治疗呼吸道疾患已取得一定的效果.为了提高疗效,我们以气管炎菌苗免疫正常猪,制成特异性转移因子,使受体被致敏的淋巴细胞对抗原的反应更具针对性.经两次临床考核,双盲对照人源转移因子对PEF、1∶2000 OT试验、LTR等指标检测,显示作用相似,但CD_8^+指标则差异显著(P<0.05).可能成为减轻或阻止其咳喘症状发生的机制之一.作为一种免疫调节剂,我们认为特异性转移因子可作为慢性阻塞性肺部疾患较好的早期治疗措施之一.

Treatment of respiratory tract diseases with health human transfer factor (TF) had showed some advantages. To raise curative effect, we immunized health pig with tracheobronchitis vaccine and obtained specific TF which made the reaction between the antigen and the sensitized receptor of lymphocyte becoming more particular. Under double blind control of two times clinical examination, contrast with human TF, the specific TF had similar effect on PEF, 1 : 2000 OT test and LTR, etc. But CD_8 index showed that the difference between human TF and specific TF was very obvious (P< 0.05). It might be a possible mechanism which was able to reduce or stop the development of cough and asthma. We consider that, as an immunomodulator, specific TF may have better effect when used at the early period of treatment in chronic obstructive pulmonary diseases.