摘要
目的 探讨中国汉族人群雌激素受体 (ER)基因PvuⅡ和XbaⅠ酶切多态性与脑梗死的相关性。方法 采用病例 对照研究方法和PCR RFLP方法 ,检测 2 34例脑梗死和 2 59例非脑血管病患者的ER基因PvuⅡ及XbaⅠ多态性 ,用多元Logistic回归模型分析与脑梗死的相关性。结果 经年龄、性别、吸烟、饮酒、文化程度、高血压、糖尿病、冠心病、高脂血症调整后可见 :(1 )ER基因PvuⅡ酶切多态性的Pp基因型致脑梗死发病危险性显著增加 (OR =1 97,95 %CI:1 2 1～ 3 2 1 ) ;(2 )ER基因XbaⅠ酶切多态性与脑梗死无显著相关性 ;(3)ER基因PPXx Ppxx基因型经高血压、高脂血症分层前后均致脑梗死发病危险性显著增加 (OR值分别为 1 67,2 52及 2 1 8,P <0 0 5) ;(4)ER基因PvuⅡ酶切多态性与高血压、糖尿病、高脂血症对脑梗死的发生具有明显的协同作用。
Objective To explore the association between estrogen receptor (ER) gene PvuⅡ and XbaⅠ polymorphisms and cerebral infarction among Chinese Han people Methods Samples of peripheral blood white cell were extracted among 234 patients with cerebral infarction, aged 63 9±10 3, and 259 controls without cerebrovascular disease, aged 59 2±9 2, all of Chinese Han nationality PCR RFLP and genotyping of ER PvuⅡ and XbaⅠ polymorphisms were performed Multiple Logistic regression analysis was made to explore the risk factors for cerebral infarction Results After adjustment for major confounders including age, gender, smoking, alcohol drinking, education, history of hypertension, diabetes mellitus, coronary artery disease and hyperlipoidemia, multiple Logistic regression analysis showed that: (1) The Pp genotype of ER PvuⅡ polymorphism increased the risk of cerebral infarction significantly ( OR =1 97, 95% CI : 1 21～3 21); (2) The ER XbaⅠ polymorphism was not in association with cerebral infarction significantly; (3) The PPXx/Ppxx genotypes increased the risk of cerebral infarction significantly ( OR =1 67,2 52 and 2 18 respectively, P <0 05) before or after all subjects were stratified by the history of hypertension or hyperlipoidemia; and (4) The positive interaction between the ER PvuⅡ polymorphism and the presence of hypertension or diabetes or hyperlipoidemia could increase the risk of cerebral infarction significantly Conclusion ER gene may be one of the genetic candidate genes for cerebral infarction among Chinese Han population
出处
《中华医学杂志》
CAS
CSCD
北大核心
2002年第21期1443-1446,共4页
National Medical Journal of China
