胎儿睾丸移植治疗男性低睾酮血症的临床应用

Fetal Testis Transplantation for the Treatment of Male Hypoandrogenism

目的:探讨胎儿睾丸移植在男性低睾酮血症治疗中的临床应用价值。方法:利用显微外科技术,以胎儿睾丸作移植体,为8例男性低睾酮血症患者施行了胎儿睾丸移植术。结果:术后5个月,8例患者的血清睾酮水平明显升高,性欲、性功能及第二性征明显改善,移植睾丸体积较术前增大。结论:胎儿睾丸移植治疗男性低睾酮血症有效,且胎儿睾丸免疫原性低,具有较高的临床应用价值。

Objective: To investigate the value of the clinical application of fetal testis for the treatment of male hypogonadism. Methods: We had performed the testicular transplantation to cure 8 patients suffered from hypogonadism with the fetal testis as donor tissue. Results: All patients had a significantly increased level of serum testosterone, and the male secondary sexual characteristics and the sexual desire were improved. The size of testis was larger than that before operation. Conclusion: Fetal testis transplantation is an effective method to cure male hypogonadism and has great value of clinical application for its weak immunogenicity.