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AnnexinⅡ介导的纤维蛋白溶解调控机制研究 被引量：2

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摘要 AnnexinⅡ是新近发现的纤维蛋白溶解酶原 (PLG)和组织型纤溶蛋白溶解酶原激活物 (t PA)的共受体 ,是Ca2 + 介导具有高亲和力的磷脂结合蛋白。其介导血管内外纤维蛋白溶解 ,对保持机体内环境稳定具有重要作用。An nexinII调控异常及有害因子的作用 ,可导致血栓性疾病和动脉硬化症 ;AnnexinⅡ异常高表达所引起纤溶亢进 ,是白血病等恶性肿瘤出血合并症重要机制之一。对其干预和调控可能为治疗上述病症提供新思路 。
作者 张晓晖
机构地区 华中科技大学同济医学院附属协和医院血液科
出处 《国外医学（生理病理科学与临床分册）》 2002年第5期503-505,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 AnnexinⅡ 纤维蛋白溶解 纤维蛋白溶解原 T-PA 受体
分类号 R331 [医药卫生—人体生理学]
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参考文献23

  • 1Kim J, Hajjar KA. Annexin Ⅱ: a plasminogen-plasminogen activator coreceptor[J]. Front Biosci,2002,7:D341 - 348.
  • 2Choi KS, Fitzpatrick SL, Filipenko NR, et al. Regulation of plasmindependent fibrin clot lysis byannexin Ⅱ heterotetramer[J] .J Biol Chem,2001,276(27) :25212 - 25221.
  • 3Abou-Agag LH, Tabengwa EM, Tresnak JA, et al. Ethanol-induced increased surface-localized fibrinolytic activity in cultured human endothelial cells: kinetic analysi s[J]. Alcohol Clin Exp Res,2001,25(3):351-361.
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  • 5Menell JS, Cesarman GM, Jacovina AT, et al. Annexin Ⅱ and bleeding in acute promyelocytic leukemia[J]. N Engl J Med, 1999,340(13): 994- 1004.
  • 6Hawley SB, Green MA, Miles LA. Discriminating between cell surface and intracellular plasminogen-binding proteins: heterogeneity in profibrinolytic plasminogen-binding proteins on monocytoid cells. Thromb Haemost[J]. 2000, 84(5) :882- 890.
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  • 9Kristoffersen EK, MatreR.Sufface annexinⅡSurface annexinⅡon placental membranes of the fetomatemal interface[J]. Am J Reprod Immunol,1996,36(3): 141 - 149.
  • 10Falcone DJ, Borth W, Khan KM, et al. Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin Ⅱ[J]. Blood, 2001,97(3): 777-784.

同被引文献20

  • 1张之南.血液病诊断及疗效标准[M].3版.北京:科学出版社,2008:1.
  • 2Avvisati G. Coagulopathy in APL: a step forward [J]. Blood, 2012,120(1) :4-6.
  • 3Tilburg N H, Rosrndaal F R,Bertina R M,et al. Throm bin activable-fibrinolysis inhibitor and the risk for deep vein thrombosis[J]. Blood, 2000,95 (9) : 2855-2859.
  • 4Gumus II ,Kargili A, Karakurt F,et al. Levels of throm- bin activatable fibrinolysis inhibitor in gestational diabetes mellitus[J]. Gynecol Endocrinol, 2013,29 (4) : 327-330.
  • 5Tregouet D A, Sehnabel R, Alessi M C, et al. Activated thrombin activatable fibrinolysis inhibitor levels are asso- ciated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study[J]. J Thromb Haemost,2009,7(1) :49-57.
  • 6Meiiers J C,Oudiik E J,Mosnier L O,et al. Reduced ae- tivity of TAFI(thrornbin activatable fibrinolysis inhibitor) in acute promyelocytie Ieukaemia[J]. Br J Haematol, 2000,108(3):518-523.
  • 7刘素珍.黄芩苷对OX-LDL导致动脉粥样硬化的干预作用[J].医学信息,2015,(11):360-360.
  • 8Li Q, Huang QR. et al.Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway [ J ]. Apoptosis, 2010,15 (6) : 693-704.
  • 9Zhang Y, He M., Huang QR. Pharmacological activation of PPARγ ameliorates vascular endothelial insulin resistance via a non-canonical PPARγ-dependent nuclear factor-kappa B trans-repression pathway[ J]. Eur J Pharmacol, 2015, 754: 41-51.
  • 10Zhong X J, Shen XD, Huang QR. Osteopontin-induced brown adipogenesis from white preadipocytes through a PI3K-AKT dependent signaling[ J], Biochem Biophys Res Commun, 2015, 459: 553-559.

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国外医学（生理病理科学与临床分册）
2002年 第5期

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