洗必泰醋酸盐等一组化合物阴道用药可行性研究

Practicability Study on A Group of Vigilant Chemical Compounds Including Chlorheridine Diacetate

目的 :从一组化合物中筛选具有预防性传播疾病 (STD)病原体的体外杀精药物。 方法 :用洗必泰醋酸盐等一组化合物进行体外杀精试验和抑杀菌试验。 结果 :2 0s内洗必泰醋酸盐和对硝基苯酚抑制人精子的药物最低浓度均为 1.2 5g L。体外抑杀菌试验表明 ,洗必泰醋酸盐和对硝基苯酚对白色念珠菌 (2 8株 )最低抑菌浓度(MIC)和最低杀菌浓度 (MBC)分别为 0 .12 5～ 0 .5 0 0g L和 0 .2 5 0～ 1.0 0 0g L ;两药物对淋病奈瑟菌 (2株 )的最低抑菌浓度为 0 .0 12 5～ 0 .5 0 0 0g L。 结论 :洗必泰醋酸盐和对硝基苯酚不仅具有较强的杀精效果 。

Objectives: To test in vitro the spermatozocidine drug which can also prevent sex transmitting diseases (STD) pathogens.Methods: Chlorheridine diacetate and other three chemical compounds were applied in vitro spermatozocidine and sperm inhibitting tests. Results: The lowest concentrations of chlorheridine diacetate and p nitrophenol which can inhibit human sperm in 20 seconds were 1.25 mg/ml. The minimal inhibitory concentration and minimal bactericidal concentration of chlorheridine diacetate and p nitrophenol on Streptococcus albus Stemberg were 0.125 to 0.50 mg/ml and 0.25 to 1.00 mg/ml. Conclusions: Chlorheridine diacetate and p uitrophenol have strong spermatozocidine and antibacteria effects.