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附睾精子蛋白P34H与男性生殖 被引量：9

Epididymal Sperm Protein P34H and Male Reproduction
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摘要 哺乳动物精子在附睾转运过程中会获得精 卵相互作用所必需的精子表面蛋白。P34H是由人附睾上皮细胞分泌并定位于精子顶体的精子膜蛋白 ,属于短链脱氢酶 还原酶 (SDR)超家族成员。初步研究表明 ,P34H能够介导精子 卵透明带的结合 ,可作为附睾精子成熟的标志物 ,且低水平的附睾精子蛋白P34H与原发性男性不育显著相关。因此 ,精子表面P34H的水平可以作为男性不育症的一个辅助诊断指标。本文对附睾精子蛋白P34H的分子生物学特性、基因的表达与调控。 During epididymal transit, mammalian spermatozoa acquire new surface proteins that are necessary for gamete interaction. P34H, a member of the short chain dehydrogenase/reductase(SDR) superfamily, is acquired on the acrosomal cap of human spermatozoon during its maturation arising within epididymis. P34H has been shown to be involved in sperm zona pellucida interaction. Research revealed that the occurrence of low concentration of sperm protein P34H were significant amongst the idiopathic infertile male population and P34H protein could also be considered as a marker of epididymal sperm maturation in human. Therefore the level of sperm protein P34H is proposed to be a auxiliary diagnostic tool for male infertility. This paper reviews the molecular properties and regulation of the expression of P34H and its association with male reproduction.
作者 夏欣一 黄宇烽 许晓风
机构地区 南京军区南京总医院生殖遗传研究室 南京军区南京总医院生殖遗传研究室 南京师范大学生命科学学院
出处 《中华男科学杂志》 CAS CSCD 2002年第5期356-358,362,共4页 National Journal of Andrology
关键词 附睾精子蛋白 P34H 男性生殖 精子成熟 Epididymal sperm protein P34H Sperm maturation Male reproduction
分类号 R339 [医药卫生—人体生理学]
  • 相关文献

参考文献20

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二级参考文献82

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共引文献30

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引证文献9

二级引证文献27

中华男科学杂志
2002年 第5期

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