人参多糖对X射线照射小鼠骨髓细胞染色体畸变和造血干、祖细胞的影响

EFFECTS OF POLYSACCHARIDES OF GINSENG (PSG) ONHAEMOPOIETIC STEM, PROGENITOR CELLS ANDCHROMOSOME ABERRATION OF BONE MARROWCELLS IN X-IRRADIATED MICE

本实验观察了人参多糖对X射线照射小鼠骨髓细胞染色体和造血干、祖细胞的影响。结果表明:人参多糖对受不同剂量X射线照射小鼠骨髓CFU—S和CFU—GM均有显著的保护作用,3.0Gy X射线照射后7天,人参多糖组小鼠骨髓CFU—S和CFU-GM仍高于对照组。同时发现,人参多糖对X射线诱发的染色体畸变率有明显的降低作用。

The effects of PSG injection before X - irradiaton on haemopoietic stem, progenitor cells and chromosome aberration of bone marrow cells in mice were investigated. The results showed that the colonies of CFU -S and CFU -GM in PSG group were significantly higher than that in the control group. The time courses of CFU-S and CFU-GM of bone marrow in the X -irradiated mice indicated that the effects still existed on the 7th day after irradiation with 3. 0Gy X -rays. Simultaneously, it was found that the rate of chromosome aberration or the rate of aberrated cells in PSG group was lower than that in the control group.