期刊文献+

CD_(44)与肿瘤关系的研究进展

下载PDF
导出
摘要 恶性肿瘤具有在多种因素介导下侵袭血管和转移的特性.瘤纽胞在侵袭和转移过程中,从原发瘤体分离,穿越细胞与细胞之间的基质、血管内皮及皮下基底膜,最后进入转移灶.因此调节细胞和细胞、细胞和基质之间相互作用的因素起关键作用[1].粘附分子正是这样一类介导细胞与细胞、细胞与细胞外基质间粘附作用的膜表面糖蛋白,它们在肿瘤的发生和发展中发挥重要作用.CD44就是一种存在于多种细胞表面的粘附分子.近年来,CD44与肿瘤关系的研究引起人们的高度重视,本文就该研究的发展状况作一概述.
作者 吴春华
机构地区 湖北省医学会
出处 《医学理论与实践》 2002年第11期1244-1245,共2页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献10

  • 1[1]Albelda SM, Buck CA. Integrins and other cell adhesion molecules,FASEB J, 1990;4:2868 ~ 2880
  • 2[2]Haynes BF, Liao HY, Patton KL, et al. The transmembrane hyaluronidase receptor (CD44): multiple functions, multiple forms. Cancer Cells, 1991;3:347 ~ 350
  • 3[3]Matzumura Y, Tarin D. Significance of CD44 gene products for cancer diagnosis and disease evaluation. Lancet, 1992;340(8827): 1049 ~ 1053
  • 4[4]Screaton GR, Martyn V, Davi DG, et al. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA, 1992; 89 ( 24 ): 12160 ~12164
  • 5[5]Albelda SM, Biology of disease role of integrins and other cell adhesion molecules in tumor progression and metastasis (Review). Lab Invest,1993,68:4 ~ 17
  • 6[6]Koopman G, Griflione AW, Ponta H, et al. CD44 splice variants: expression on lymphocyte and in nooplasia. Res Immunol, 1993;144:750 ~ 754
  • 7[7]Rudy W, Hofmann M, Schwarts - Albeiz R, et al. Two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splices to confer metastatic behaviour. Cancer Res, 1993; 53:1262 ~ 1268
  • 8[8]Wielen GA, Heider K, Offerhaus G, et al. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res, 1993;53:4754 ~ 4756
  • 9[9]Joseph M, Julie E, Hines, et al. CD44 is expressed in hepatocellular carcinomas showing vascular invasion, 1996; 179: 74 ~ 79
  • 10[10]Tatsuo F,Toshiki H, Hironoku N, et al. Expression of proliferating cancer cell nuclear antigen and CD44 variant isoforms in the primary and metastatic sites of nonsmall cell lung carcinoma with intrapulmonary metastases, Cancer, 1999;86(7): 1174 ~ 1181

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部