血浆一氧化氮水平与肝功能在梗阻性黄疸患者中的相关分析

Multiple Correlation Analysis between Level of Plasma Nitric Oxide and Liver Fun ction in Patients with Obstructive Jaundice

目的 :初步探讨梗阻性黄疸患者血浆一氧化氮 (NO)变化规律及可能的机制。方法 :19例梗阻性黄疸 (梗黄组 )患者不伴感染及其它严重合并症 ,其中良性梗阻6例 ,恶性梗阻13例。同期非梗阻性无感染胆囊疾病患者9例为对照 ,检测血浆NO及肝功能 ,并将NO与肝功能行相关分析。结果 :梗黄组与对照组相比 ,NO水平显著性降低 ,其中恶性梗阻组与良性胆道梗阻组相比 ,血NO有显著性差异(P<0.01) ,恶性梗阻组血浆NO进一步降低。NO与肝功能相关分析结果提示NO与总胆红素 (TB)及碱性磷酸酶 (ALP)呈负相关 ,经检验有显著性意义。结论 :(1)梗阻性黄疸时NO水平降低。 (2)梗阻性黄疸时血浆NO水平与TB。

Objective:To investigate the rule of plasma nitric oxide(NO)change in patie nts with obstructive jaundice and its possible mechanism.Methods:The level of pl asma NO and liver function were measured in 19 patients with obstructive jaundic e(benign:6,malignant:13)and 9 normal controls.The multiple correlation analysis between the level of plasma NO and liver function was made.Results:The level of plasma NO in patients with obstructive jaundice was significantly lower than tha t in controls.The level of plasma NO in patients with malignant obstructive jaun dice was significantly lower than that in patients with benign obstructive jaund ice(P<0.01).There was a remarkably negative correlation between the level of pla sma NO and TB/ALP( NO/TB=-0.663 0,P=0.013 5; NO/ALP=-0.740 0,P=0.003 8).Conc lusion:(1)The level of plasma NO decreases in patients with obstructive jaundice .(2)There is a negative correlation between the level of plasma NO and the obstr uctive degree.