病毒性肝炎患者血清视黄醇结合蛋白和前白蛋白的检测及意义

Significance of Measurement of Serum Retinol-binding Protein and Prealbuminin Patients with Viral Hepatitis

目的 :探讨视黄醇结合蛋白 (RBP)和前白蛋白 (PA)在病毒性肝炎患者血清中的水平及两者的相关性及其临床意义。方法 :用免疫散射比浊法检测113例病毒性肝炎患者血清RBP和PA水平 ,设健康献血员20例作对照。结果 :血清RBP和PA水平与肝脏受损害程度相关 ,随着肝功能损害逐步加重RBP和PA水平均不同程度降低 ,且均以重型肝炎水平最低。血清RBP与PA呈正直线相关 ,两者相关系数r为0 83。结论 :血清RBP和PA的水平与肝脏功能的损害相关 ,随着肝病的加重两者水平逐渐下降 ,可以作为反映肝脏损害程度的指标。且RBP的半衰期明显短于PA ,比PA更敏感 。

Objective:To study the relationship between serum retinol_binding protein(R BP)and prealbumin(PA)in patients with viral hepatitis and its clinical significa nce.Methods:Nephelometric assay was used to detect serum RBP and PA in 113 patie nts with viral hepatitis.Twenty healthy persons were control.Results:Levels of s erum RBP and PA were correlative with the degree of liver damage.The level of se rum RBP and PA declined with thedecrease of liver function.There was a positive correlation between serum RBP an d PA,and the correlation coefficient was 0.83.Conclusion:The level of serum RBP and PA is a marker to reflect the degree of liver damage.The half life of RBP is significantly shorter than that of PA RBP is more sensitivity than PA and can be used to predict liver damage.