青年乳腺癌71例的临床分析

Clinical analysis of 71 young women with breast carcinoma

目的 了解青年时期乳腺癌与中老年乳腺癌在临床上的差异。方法 回顾性分析 2 0年间 810例女性乳腺癌的病例。其中青年组 71例 (≤ 35岁 ) ;中老年 739例 (>35岁 )作为对照组。分析包括 :诊断过程、肿瘤分期、病理分型、治疗措施、5年生存率等。结果 两组比较 :发病至就诊的时间青年组 (5 6± 4)d较对照组 (35± 3)d长 ;u =2 .33;P <0 0 5 ;首诊失误率高于对照组 (5 6 3%vs2 8 6 % ;χ2 =2 3 38;P <0 0 5 ) ;侵袭性肿瘤的构成比高于对照组 (91 5 %vs 82 4% ;χ2 =3 84;P <0 0 5 ) ;完成计划辅助治疗的人数多于对照组 (70 7%vs 5 6 5 % ;χ2 =4 80 6 ;P <0 0 5 )。两组间 5年生存率的差异无显著意义 [5 5 6 % (2 0 / 36 )vs 6 2 5 % (192 / 30 7) ;χ2 =0 6 6 6 ;P <0 0 5 ]。结论 青年乳腺癌患者的临床特征与对照组间有较多的差异 。

Objective To study the clinical characteristics in young women with breast cancer.Methods Clinical data on 71 young breast cancer cases (under 35 years) out of a total 810 female cases during a period of 20 years were retrospectively analyzed. Result Delayed medical consultation was more often seen in young patients(56±4)?d vs (35±3)?d; u=2.33; P<0.05) with higher misdiagnosis rate (56.3% vs 28.6%;χ 2=23.38; P<0.05). Young cases tended to be at a more advanced stage of breast cancer(91.5% vs 82.4%;χ 2=3.84 ; P<0.05) and more compliant to adjuvant therapy(70.7% vs 56.5%;χ 2=4.806; P<0.05). The 5 year′s survival rate between the two groups was similar [55.6%(20/36) vs 62.5%(192/307);χ 2=0.666; P<0.05].Conclusions The prognosis of young female breast cancer patient is as favourable as elder patients.