孕妇血浆中游离胎儿DNA在产前诊断中的研究进展
摘要
用妊娠妇女外周血中的胎儿DNA进行产前诊断是目前产前诊断研究的热点,从妊娠妇女外周血中得到胎儿DNA主要有两种途径,一种是从妊娠妇女外周血中富集纯化胎儿细胞,另一种是从孕妇血浆/血清中直接提取游离的胎儿DNA。将对孕妇血浆中的胎儿DNA在非侵入性产前诊断中的应用及存在的问题进行综述。
参考文献21
-
1Lo YM, Corbetta N, Chamberlain PF, et al. Presence of fetal DNA in maternal plasma and serum. Lancet, 1997,350(9076):485-487
-
2Lo YM, Tein MSC, Lau TK, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for nonin vasive prenatal diagnosis. Am J Hum Genet, 1998,62:768-775
-
3Lo YM, Zhang J, Leung TN, et al. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet, 1999,64:218-224
-
4Lo YM. Molecular testing of urine: catching DNA on the way out [Editorial]. Clin Chem, 2000,46:1039-1040
-
5Honda H, Miharu N, Ohashi Y, et al. Successful Diagnosis of fetal gender using conventional PCR analysis of maternal serum. Clin Chem, 2001,47:41-46
-
6Zhong XY, Holzgreve W, Hahn S. Detection of fetal Rhesus D and sex using fetal DNA from maternal plasma by multiplex polymerase chain reaction (PCR). BJOG, 2000,107:766-769
-
7Farina A, Caramelli E, Concu M, et al. Testing normality of fetal DNA concentration in maternal plasma at 10-12 completed week's gestation: a preliminary approach to a new marker for genetic screening. Prenat Diagn, 2002,22:148-152
-
8Poon LLM, Leung TN, Lau TK, et al. Presence of fetal RNA in maternal plasma. Clin Chem, 2000,46:1832-1834
-
9Zhong XY, Burk MR, Troeger C, et al. Fetal DNA in aneuploid fetuses is elevated in pregnancies with aneuploid fetuses. Prenat Diagn, 2000,20:795-798
-
10Zhong XY, Laivuori H, Livingston JC, et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in plasma of pregnant women with preeclampsia. Am J Obstet Gynecol, 2001,184:414-419
-
1张汉凤,陈汉平.非侵入性产前诊断技术[J].中国实用妇科与产科杂志,2000,16(11):699-700. 被引量：3
-
2魏成芳,赵云.非侵入性产前诊断的研究进展[J].河北医学,2009,15(10):1253-1256. 被引量：1
-
3赫梅德,张元珍,李家福.非侵入性产前诊断研究进展[J].国外医学（妇幼保健分册）,2002,13(3):106-107. 被引量：4
-
4骆建云.利用孕妇外周血作非侵入性产前检查的研究进展[J].实用妇产科杂志,2002,18(1):17-19. 被引量：1
-
5刘红,左伋.孕妇血中胎儿细胞的富集纯化及其存在问题[J].中国优生与遗传杂志,1998,6(6):4-5.
-
6周德兰,王海琦.孕妇外周血中的胎儿DNA行产前诊断的研究进展[J].中国优生与遗传杂志,2004,12(2):1-3. 被引量：1
-
7文献推荐[J].中国产前诊断杂志（电子版）,2008(1):60-62.
-
8马建鸿,张元珍,胡伦颖,王燕.非侵入性产前诊断方法的研究进展[J].国外医学（妇幼保健分册）,2001,12(4):157-159. 被引量：1
-
9解珺淑,王山米,张晓红.非侵入性产前诊断研究及临床应用新进展[J].中国妇产科临床杂志,2012,13(3):228-230. 被引量：1
-
10张艳,迟洪滨,胡桂英.孕妇外周血中胎儿有核红细胞的富集与纯化及其在非侵入性产前诊断中的应用[J].国外医学（遗传学分册）,2001,24(5):266-269. 被引量：1
