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哺乳动物生精的重要因子:cAMP应答元件调控因子 被引量：5

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摘要 环磷酸腺苷(cAMP)应答元件调控因子(CREM)是cAMP相关转录因子,在睾丸内用不同的启动子和变位剪接能产生CREM阻遏因子和激活因子转录产物。CREM激活因子在减数分裂后单倍体生殖细胞中高表达,是精子细胞成熟所必需的。啮齿类,猴和人类的睾丸CREM表达分析结果显示CREM对哺乳动物睾丸中精子细胞的发育很重要。而且已经鉴别出许多单倍体生殖细胞中CREM的靶基因。生精紊乱和精子细胞成熟阻滞的男性有异常的CREM表达和变位剪接。总之,许多证据表明CREM对哺乳动物精子细胞的成熟有重要作用。
作者 赵龙梅 裴开颜 贾孟春
机构地区 国家计划生育委员会科学技术研究所
出处 《国外医学（计划生育分册）》 2002年第4期225-229,共5页
关键词 生精 应答元件调控因子 男性学 CREM 附睾 人类 睾丸 环磷酸腺苷
分类号 R346 [医药卫生—基础医学]
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参考文献20

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同被引文献50

  • 1李泽廷,桂耀庭,蔡志明.精子发生中几个关键基因的研究进展[J].国际泌尿系统杂志,2006,26(2):240-244. 被引量：3
  • 2于影,于志民,于沿奎.应用GnRH提高奶牛受胎率的几点体会[J].黑龙江动物繁殖,2007,15(4):33-34. 被引量：7
  • 3Nantel F,Monaco L,Foulkes NS,et al.Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice[J].Nature,1996,380 (6570):159-162.
  • 4Krausz C,Sassone-Corsi P.Genetic control of spermiogenesis:insights from the CREM gene and implications for human infertility[J].Reprod Biomed Online,2005,10(1):64-71.
  • 5Sassone-Corsi P.Unique chromatin remodeling and transcriptional regulation in spermatogenesis[J].Science,2002,296(5576):2176-2178.
  • 6Stelzer G,Don J.Atcel:a novel mouse cyclic adenosine 3',5' monophos-phate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids[J].Endocrinology,2002,143(5):1578-1588.
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  • 8Weinbauer GF,Behr R,Bergmann M,et al.Testicular cAMP responsive element modulator(CREM) protein is expressed in round spermatids but is absent or reduced in men with round spennatid maturation arrest[J].Mol Hum Reprod,1998,4(1):9-15.
  • 9张路培,张小辉,许尚忠,高雪,任红艳,陈金宝.牛GDF9和BMP15基因遗传变异与双胎性状的关系研究[J].畜牧兽医学报,2007,38(8):800-805. 被引量：21
  • 10Krausz C,Sassone-Corsi P.Genetic control of spermiogenesis:insights from the CREM gene and implications for human infertility.Reprod Biomed Online,2005,10(1):64-71.

引证文献5

二级引证文献22

国外医学（计划生育分册）
2002年 第4期

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