不同浓度氮酮对黄芩苷体外透皮吸收的影响

Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro

目的研究氮酮对黄芩苷体外透皮吸收的影响。方法以裸鼠皮肤为实验屏障,观察氮酮浓度(体积比)分别为0、2%、4%、6%、8%、10%时黄芩苷透皮吸收速率常数。结果氮酮浓度为0、2%、4%、6%、8%、10%时黄芩苷的透皮吸收速率常数分别为76.07、89.23、167.36、238.61、200.45、171.49μg·cm-2·h-1。结论氮酮可以促进黄芩苷的透皮吸收,在实验浓度范围内,氮酮浓度为6%时有最大的透皮速率常数。

Obj ective To study the effects of azone on the percutaneous absorption of baicalin in vitro. Methods Using the skin of nude mice as the cutaneous barrier, the rat e constants of percutaneous absorption of baicalin at various concentrations of Azone were determined. Results The rate constants were 76.07, 89.23, 167.36, 23 8.61, 200.45 and 171.49 ìg穋m-2 穐-1 re-spectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6% , 8%, and 10%. Conclusion Azone can enhance percutaneous absorption of baicalin , exerting its maximum effect at the concentration of 6%.