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端粒DNA长度检测方法 被引量：3

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摘要 端粒(Telomeres)位于染色体末端,由高度重复的DM序列(人类为TTAGGG)和结合蛋白所构成,保护染色体免遭熔合、重组和降解.
作者 葛璐璐 陈晓晖 刘超 王穗保
机构地区 广州市刑事科学技术研究所
出处 《中国法医学杂志》 CSCD 2002年第5期314-316,共3页 Chinese Journal of Forensic Medicine
关键词 端粒 DNA长度 检测方法 荧光标记原位杂交 年龄鉴定 法医学
分类号 D919 [医药卫生—法医学]
  • 相关文献

参考文献24

  • 1[1]Urquidi V, Tarin D, Goodison S. Role of telomerase in cell senescence and oncogenesis [ J] . Ann Rev Med, 2000, 51:65
  • 2[2]Blackburn EH. Telomere states and cell fates [ J ] . Nature, 2000, 408:53
  • 3[3]Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts [J] . Nature, 1990, 345 (6274):458
  • 4[4]Hastie ND, Dempster M, Dunlop MG, et al. Telomere reduction in human colorectal carcinoma with ageing [J] . Nature, 1990, 346(6287): 866
  • 5[5]Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts [J] . Proc Natl Acad Sci USA, 1992, 89 (21): 10114
  • 6[6]Allshire RC, Gosden JR, Cross SH, et al. Telomeric repeat from T thermophila cross- hybridizes with human telomerase [ J ] . Nature, 1988, 332:656
  • 7[7]Lange T, Shiue I, Myers R, et al. Structure and variability of human chromosome ends [J] . Mol Cell Biol, 1990, 10:518
  • 8[8]Iwama H, Ohyashiki K, Ohyashiki J H, et al. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals [J] . Hum Genet, 1998, 102(4): 397
  • 9[9]Lindsey J, McGill - NI, Lindsey - LA, et al. In vivo loss of telomeric repeats with age in humans [J] . Mutat Res, 1991, 256:45
  • 10杨仕明,房殿春,罗元辉,鲁荣,刘为纹.不同年龄供体正常胃粘膜端粒状态分析[J].第三军医大学学报,1999,21(2):126-128. 被引量：6

二级参考文献1

  • 1Egan C A，Invest Ophthalmol Vis Sci，1998年，39卷，3期，648页

共引文献5

同被引文献36

  • 1[2]Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts [J].Nature, 1990,345 (6274):458.
  • 2[3]Steven LZ, Paul P, YanRu F, et al. Rapid telomere shortening in children[J]. Blood, 1999, 93(9): 2824.
  • 3[4]Robert W, Frenck JR, Elizabeth H, et al. The rate of telomere sequence loss in human leukocytes varies with age[J]. Proc Natl Acad Sci USA, 1998,95:5607.
  • 4Allshire RC,Gosden JR,Gross SH,et al.Telomeric repeat from T thermophilia cross-hybrididizes with human telomerase[J].Nature,1988,322(6165):656-659.
  • 5de Lange T,Shiue I,Myers R,et al.Structure and variability of human chromosome ends[J].Mol Cell Biol,1990,10(2):518-527.
  • 6Martens UM,Brass V,Engelhardt M,et al.Measurement of telomere length in haematopoietic cells using in situ hybridization techniques[J].Biochem Soc Trans,2000,28(2):245-250.
  • 7Baerlocher GM,Mak J,Tien T,et al.Telomere length measurement by fluorescence in situ hybridization and flow cytometry:tips and pitfalls[J].Cytometry,2002,47(2):89-99.
  • 8Kim NW,Piatyszek MA,Prowse KR.Specific association of human telomerase activity with immortal cells and cancer[J].Science,1994,266(5193):2011-2015.
  • 9Ishikawa F.Regulation mechanisms of mammalian telomerase.A review[J].Biochem,1997,62(11):1332-1337.
  • 10Moore MA.Stem cell proliferation:ex vivo and in vivo observations[J].Stem Cells,1997,15(Suppl 1):239-248.

引证文献3

二级引证文献10

中国法医学杂志
2002年 第5期

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