腰椎椎管狭窄症患者脑脊液中神经肽的变化与临床表现的关系

The correlation between SP,VIP levels in cerebrospinal fluid and clinical manifestations in patients with lumbar spinal stenosis

目的探讨腰椎椎管狭窄症患者脑脊液中P物质(SP)、血管活性肠多肽(VIP)含量变化以及与临床表现间的关系。方测定35例腰椎椎管狭窄症患者行走能力,VAS疼痛程度评定,感觉、运动、腱反射改变及直腿抬高试验结果及脑脊液中神经肽含量并进行相关性分析。结果腰椎椎管狭窄症患者脑脊液中SP、VIP含量明显高于对照组(P<0.05),脑脊液中SP、VIP水平与行走力呈显著负相关(P<0.05),与疼痛评分呈非常显著(P<0.01)或显著(P<0.05)正相关。临床体征阴性组与阳性组间脑脊液SP及VIP含量差异无显著性意义(P>0.05)。结论腰椎椎管狭窄症患者脑脊液中SP、VIP含量明显升高,且行走能力严重障碍升高更加明显。表明上述改变与神经源性间歇性跛行的发生存在着显著的相关关系。而与临床上是否出现感觉、运动、腱反射、直抬高角度等的改变无关。

Objective To examine the correlation between t he clinical manifestations and cere brospinal fluid neuropeptides leve ls of the patients with lumbar spinal stenosis.Methods The cerebrospinal fluid neuropepti des levels,walking ability,VAS,straight leg rate and the disturbance of sense,motor,tendon reflex were tested in 35patients with lumbar spinal stenosis.And the correlation was analyzed.Results Compared with healthy volunteers,t he SP and VIP level were significantly higher in the patients with lumbar s pinal stenosis.There was sta-tistically positive correlation between SP,VIP level and walking abili ty,and negative correlation between SP,VIP level and VAS.Neither SP nor VIP was correlation with straigh t leg raising test or the disturbance of sense,motor and tendon reflex.Conclusion The higher SP and VIP level were observed in the patients with lumbar spinal stenosis.There wa s statistically correlation betwee n SP,VIP and walking ability.Neither SP nor VIP was correlation with straight leg raising test or the disturban ce of sense,motor and tendon reflex.