妊娠高血压综合征患者血清人胎盘催乳素测定与胎盘病理检查分析

Measurement of human placental lactogen and checking of placenta pathology cases of pregnancy induced hypertension syndrome

目的 :探讨妊娠高血压综合征 (妊高征 )患者血清人胎盘催乳素 (HPL)水平的变化与胎盘病理的关系。方法 :选择重度妊娠高血压综合征患者 33例为妊高征组 ,正常晚期妊娠妇女 5 2例为对照组。采用放射免疫学方法检测血清中HPL值 ,于光学显微镜下 ,观察每例胎盘标本HE染色切片。结果 :妊高征组血清HPL值与对照组比较差异无统计学意义 (P >0 .0 5 ) ;胎盘病理结果显示 :妊高征组终未游离绒毛总数与对照组比较差异无统计学意义 (P >0 .0 5 ) ,含有的合体滋养细胞结节 ,细胞滋养细胞增生 ,纤维素样坏死和血管合体细胞膜的终未游离绒毛数与对照组比较差异有统计学意义 (P <0 .0 5 )。结论 :妊高征患者合体细胞结节增多 ,胎盘纤维素样坏死增多 ,血管合体细胞膜减少 ,但滋养细胞增殖 ,HPL下降不明显。

Aim: To study the the relationship of the level of human placental lactogen (HPL) and placenta pathology in normal pregnancy and pregnancy induced hypertension (PIH) syndrome. Method:A total of 33 cases of PIH and 52 cases of normal pregnant women at third trimester were selected.Serum levels of HPL were determined by radioimmunoassay and morphological changes were observed by olympus microscopy. Result: There was no significant difference in the serum level of HPL between PIH group and control( P >0.05). Difference in pathological changes (number of the placental syncytial knots, proliferation of cytotrophoblasts,and vasculo syncytial membrane) of placental bed between 2 groups was significant ( P <0.05). But there was no difference in the number of distal villi( P >0.05). Conclusion: In PIH group the serum level of HPL is not decreased because of the proliferation of trophoblast, so HPL was not a suitable parameter in monitoring placental function in PIH.