肠道肿瘤和增生性病变中GST-π与p53蛋白表达的关系

Expression of Glutathione-S-transferase-π and p53 protein in colorectal proliferotive diseases and tumors

目的 :探讨胎盘型谷胱甘肽S转移酶 (GST π)与 p53蛋白在肠道肿瘤和增生性病变中表达及相互关系。 方法 :应用免疫组化S P法检测 33例肠腺癌 ,1 5例肠腺瘤伴不典型增生 ,2 4例肠腺瘤和 1 0例肠息肉病变组织中GST π与 p53蛋白的表达情况。结果 :33例腺癌中GST π与p53蛋白的阳性表达率高达 87 88%和 84 55 % ,与其他几组相比差异有显著性 (P <0 0 1 ) ,腺瘤伴不典型增生组的表达率也较高为 80 %和 66 67%。结论 :在肠道良性增生性病变的早期就可以有GST π与p53蛋白的表达 ,随着细胞增生的明显及不典型增生到恶性变 ,表达率显著增高 ,说明GST π与p53蛋白的表达在肠道病变中与细胞的异型性呈正相关 。

Porpuse To study the expression of glutathione S transferase (GST π) and p53 in colorectal proliferative diseases and their relationship. Methods Immunohistochemical S P method was used to detect the expressino of GST π and p53 in 33 cases of colorectal carcinoma, 15 cases of adenoma with dysplasia, 24 cases of adenoma and 10 cases of polyp. Results The positive rates of GST π and p53 in colorectal carcinoma were 87 88% and 84 85%, which were significantly higher than those of another groups. The positive rates of GST π and p53 in adenoma with dysplasia were 80% and 67%, respectively. Conclusions The expression of GST π and p53 occurs at the early stage of coloreatal proliferative diseases. The expression increases from celluar proliferation to dysplasia and carcinoma. The expression of GST π and p53 may be good markers for adenocacinoma and precancerous lesion.