卵巢黏液性囊性肿瘤伴实性附壁结节

Ovarian mucinous cystic tumors with solid mural nodules

目的 :探讨卵巢黏液性囊性肿瘤伴实性附壁结节的临床病理学特点。方法 :对 2例卵巢黏液性囊性肿瘤进行光镜观察和免疫组化染色并复习文献。结果 :1例卵巢黏液性交界性乳头状囊腺瘤伴实性附壁恶性纤维组织细胞瘤结节 ,结节内瘤细胞呈多形性。 1例卵巢黏液性囊腺瘤伴实性附壁间变性癌结节 ;间变性癌结节内瘤细胞体积较大 ,胞质丰富 ,嗜酸 ,少数胞质透明 ,排列呈巢或索状 ;免疫表型 :EMA和cytokeratin阳性。恶纤组结节中肿瘤细胞AACT和vimentin阳性。结论

Purpose To study the clinicopathologic features of ovarian mucinous cystic tumors with solid mural nodules. Methods Two cases of ovarian mucinous cystic tumors were examined, microscopically and immunohistochemically. Results One case was a borderline mucinous cystadenoma with a solid mural nodule composed of malignant fibrous histiocytoma. The malignant cells tended to be pleomorphic and showed reactivity for vimentin and AACT. The another case was a ovarian mucinous cystadenoma with an anaplastic carcinoma nodule. The tumor cells in the nodule were rounded or oval in shape with abundent eosinophilic or clear cytoplasm,and arranged in cords and nests. The cells were positive for EMA and cytokeratin. Conclusion Immunohistochemistry is useful for the diagnosis, differentital diagnosis, and classification of the solid mural nodule in the ovarian mucinous cystic tumor.