摘要
研究表明,给小鼠腹腔注射HgCl_20.5和1.0mg/kg后,其诱发的微核率显著地高于蒸馏水对照组。而给小鼠腹腔注射VC50mg/kg以上,可降低HgCl_2的致微核作用,注射剂量达100和200mg/kg时,其作用更明显(P<0.001)。另外,不论是在HgCl_2染毒前4h或染毒后2h内给子VC,均可明显地降低HgCl_2的致微核作用,尤其是在HgCl_2染毒前30～60min内和染毒后30min时给VC、则其抗致微核作用愈益明显。如给小鼠饮用含VC2.5g/L的水一个月后,也可显著地降低HgCl_2的致微核作用。
HgCl2 -induced micronuclei in this study presents antagonistic effects of VC on mice.The mice were injected intraperitoneally with mercuric chloride(HgCl2),
0.5 and 1.0 mg/kg.It was found that the rate of the bone marrow polychromatic erythrocyte in HgCl2-treated mice was obviously higher than that of control groups. In the mice injected intraperitoneally with VC of 50 mg/kg or more, HgCl2-induced the rate of micronuclei decreased, especially within 30~60 min before and 30 min after the mice recieved HgCl2.The rate of micronuclei also decreased obviously after the mice drank the water of VC 2.5g/L for a month.
出处
《蚌埠医学院学报》
CAS
1992年第1期12-16,共5页
Journal of Bengbu Medical College
关键词
维生素C
氯化高汞
微核试验
vitamin C
mercuric chloride ( HgCl_2 )
micronucleus test
