肝病患者的血清透明质酸测定及其临床意义

SERUM HYALURONIC ACID IN LIVER DISEASES

本文报道用RIA测定112例各种肝病患者血清透明质酸(HA)的水平。结果如下:(1)随着肝病病程的进展,患者血清HA水平逐渐增高,即原发性肝癌(651.60±112.32μg/L)>肝硬化(437.64±123.68μg/L)>慢活肝(234.95±46.60μg/L)>慢迁肝和急性甲型肝炎(分别为83.18±39.38μg/L与82.08±30.23μg/L)>对照组(47.57±17.54μg/L)(P均<0.01)。(2)肝硬化患者,按Child分级,A级(321.14±37.17μg/L)<B级(429.00±31.90μg/L)<C级(573.07±66.72μg/L)(P均<0.01)。(3)原发性肝癌(651.60±112.32μg/L)>转移性肝癌(235.30±46.98μg/L)(P<0.001),因此,作者认为测定血清HA水平可能是肝脏疾病一个很有价值的临床试验。

Serum hyaluronic acid ( HA ) was measured by radioimmunoassay ( RIA ) in 112 patients with various liver diseases. The principal findings were the following. (l)primary hapatocellular carcinoma ( PHC ) ( 651.60±112.32 μg/L ) >cirrhosis of liver ( LC ) ( 437.64±123.68μg/L ) >chronic active hepatitis ( CAH ) ( 234.95±46.60μg/L )> chronic persistent hepatitis ( CPH ) and acute hepatitis A(AHA) ( 83.18±39.38μg/L and 82.08 ± 30.23μg/L , respectively ) >controls ( 47,57±17.54μg/L ) (P<0.01), whereas no difference was observed in the mean serum HA levels of CPH and AHA(P>0.05) . (2) In patients with LC, Child A ( 321.14±37.l7μg/L ) <Child B (429.00±31.90μg/L) <Child C (573.07±66.72μg/L ) ( P<0.01 ) , and most cases ( 34/37, 92% ) had HA values above 300μg/L. The serum HA levels were correlated significantly with of serum albumin, γ-globulin and prothronbin time. No correlation was found with total serum bilirubin and ALT. (3) The patients with PHC had a significantly higher serum HA levels than those with MHC ( 651.60± 112.32μg/L and 235.30±46.98μg/L, respectively )( P<0.001 ). Most cases of PHC had HA levels above 500μg/L . All the patients with MHC had HA levels under 300μg/L. The determination of serum HA level proves to be a valuable clinical test of liver diseases.