亚硒酸钠拮抗氯化高汞的致微核作用

ANTAGONISTIC EFFECTS OF SODIUM SELENITE ON MICRONUCLEI INDUCED BY MERCURIC CHLORIDE

本文应用微核试验方法对亚硒酸钠(Na_2SeO_3)拮抗氯化高汞(HgCl_2)致小白鼠骨髓嗜多染红细胞的微核作用进行了研究,其主要结果为:(1)Na_2SeO_3(lmg/kg)可显著地降低HgCl_2(lmg/kg)致微核作用(P<0.001);(2)Na_2SeO_3(lmg/kg)在HgCl_2染毒前2h内给予时,其微核率均较单纯HgCl_2对照组为低,但提前4h给予则未显示拮抗作用;(3)Na_2SeO_3在HgCl_2染毒后的30min内给予时具有一定的拮抗致微核作用;(4)给予小白鼠自由饮用含Na_2SeO_3(5mg/L)水一个月后也可明显地减少HgCl_2的致微核作用。

In this paper,antagonistic effects of sodium selenite (Na2SeO3) on the rate of micronuclei in the mice bone marrow polychromatic erythrocyte induced by mercuric chloride (HgCl2) was studied using the micronucleus test method. The main results are as follows : (l)The rate of micronuclei induced by the combining Na2SeO3(1mg/kg) and HgCl2(1mg/kg)was lower significantly than that of HgCl2 control group ( P <0. 001);(2)When the experimental group mice received Na2SeO3 two hours before with HgCl2,the rate of micronuclei was lower than that of HgCl2 control group,but when the mice were injected Na2SeO3 four hours before no effect was observed; (3)The antagonistic effect of Na2SeO3 on HgCl2-induced micronuclei was observed 30 min after the mice treatment with HgCl2 ;and (4)The antagonistic effect of micronuclei caused by HgCI2 also showed obviously after the mice drinking water of Na2SeO3(5mg/L)for a month.