摘要
研究目的:是为了探讨过度训练对机体免疫功能的影响及其机制。研究方法:对SD大鼠进行为期8周的力竭性游泳训练建立大鼠的过度训练模型,测定外周血液中NK细胞和IL-2的含量。研究结果和结论:运动训练后,1 h训练组中,CD_(16)^+和CD_(57)^+NK细胞以及IL-2的含量均显著高于对照组;而过度训练组中,CD_(16)^+和CD_(57)^+NK细胞以及IL-2的含量均显著低于1 h训练组和对照组。结果表明,适当的运动训练可以增加NK细胞和IL-2的含量,提高机体的免疫功能;而过度训练可以减少NK细胞和IL-2的含量,抑制机体的免疫功能。运动训练导致机体IL-2的变化可能是调节机体NK细胞的一个重要因素。
The over-training model was established by exhaustive swimming for 8 weeks,and CD_(16)^+,CD_(57)+~NK cells and interleukin-2 (IL-2) content were measured to explore the effects of over-training on immune function.The results showed that after exercise training,the number of CD_(16)^+ and CD_(57)^+ NK cells and serum IL-2 content in 1 hr training group were higher than those in control groups significantly.In over-training group,the number of CD_(16)^+ and CD_(57)^+ NK cells and serum IL-2 content were lower than those in 1 hrtraining group and in control group significantly.The results suggested that moderate exercise training might increase the number of NK cells and serum IL-2 content,and improve the immune function while over-training might cause immunosuppression by decreasing the number of CD_(16)^+ and CD_(57)^+ NK cells and serum IL-2 content.The changes of serum IL-2 content caused by exercise training might be an important factor of regulating NK cells.
出处
《体育科学》
CSSCI
北大核心
2001年第6期67-69,共3页
China Sport Science
