新发现和正在研究中的细胞凋亡蛋白抑制剂(综述)

The inhibitor of apoptosis proteins in research and newly discovered(A review)

自从杆状病毒中分离出凋亡蛋白抑制剂 (inhibitorofapoptosisproteins ,IAPs)后 ,发现的凋亡蛋白抑制剂的种类和数量逐渐增多。迄今为止 ,在人体新发现的IAPs有HIAP - 1(humanIAP -1)、HIAP - 2 (humanIAP - 2 )、XIAP(Xchromosome -likedIAP)、ML -IAP(melanocytesIAP)、Survivin和Livin等。对IAPs的发现、定位、结构。

There are many mechanisms regulating apoptosis. With the development of research in the inhibitor of apoptosis proteins(IAPs), which is one of effective inhibitor to suppress cell death induced by various stimuli, the family of IAPs have become larger and larger, since the first IAP was identified in baculovirus. Up to now, some human IAPs have been found, such as NAIP, HIAP-1, HIAP-2, XIAP, ML-IAP, surviving and Livin. It is necessary to introduce the detecting, location, structure, distribution and role of IAPs. So, the review is just to clarify the latest research progress.