Pre-exposure effect of low-dose ^(16)O^(8+) or γ-rays on testicular endocrine of mice

Ｐｒｅｅｘｐｏｓｕｒｅｅｆｅｃｔｏｆｌｏｗｄｏｓｅ１６Ｏ８＋ｏｒγｒａｙｓｏｎｔｅｓｔｉｃｕｌａｒｅｎｄｏｃｒｉｎｅｏｆｍｉｃｅＺｈａｎｇＨｏｎｇ，ＷｅｉＺｅｎｇＱｕａｎ，ＬｉＷｅｎＪｉａｎ，ＣｈｅｎＷｅｉＱｉａｎｇ，ＬｉａｎｇＪｉ...

The testes of the B6C3F 1 hybrid strain mice were irradiated with 0.05 Gy of 16 O 8+ ion / 60 Co γ ray as the pre exposure dose, and were then irradiated with 2 Gy of 16 O 8+ ion/ 60 Co γ ray as challenging irradiation dose at 4 h after pre exposure. The results show that irradiation of mouse testes with 2 Gy of 16 O 8+ ion or 60 Co γ ray significantly diminished mouse body mass,testis mass and serum testosterone. However, pre exposure with a low dose (0.05 Gy) significantly reduces this kind of effect.The relative biological effectiveness of 16 O 8+ ion was calculated with respect to 60 Co γ ray for the induction of reduction in body mass, testis mass and serum testosterone to be 1.71, 1.81 and 1.42, respectively.