Extending Bragg peak of heavy ion beam and melanoma cell inactivation measurement

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A rotating range modulator was designed and manufactured, which is applied to extend Bragg peak of heavy ion beam. Bragg curves of 75 MeV/u 16 O and 75 MeV/u 12 C ion beams through this range modulator were measured respectively and two evident spread out Bragg peaks corresponding to the modulated beams above are shown. In addition, inactivation effect of the modulated 75 MeV/u 16 O ion beam at nine different penetration depths on melanoma cells (B 16 ) was measured. Results indicate that lethal effects at the spread out Bragg peak region are larger than at the plateau of the particle beam entrance.