摘要
１ＩｎｔｒｏｄｕｃｔｉｏｎＭａｎｙｒｅｃｅｎｔｆｏｒｅｉｇｎａｎｄｄｏｍｅｓｔｉｃｒｅｐｏｒｔｓｓｈｏｗｅｄｔｈｅｈｕｍａｎｓｅｒｕｍｐｅｐｓｉｎｏｇｅｎ（ＰＧ）ｌｅｖｅｌｓｗｅｒｅｖａｌｕａｂｌｅｉｎｔｈｅｄｉａｇｎｏｓｉｓｏｆｇａｓｔｒｉｃｄｉｓ...
Serum pepsinogens I and Ⅱ (PG I, PG Ⅱ) levels were determined by PG I and PG Ⅱ RIA kits in 84 healthy controls and 128 patients of gastric diseases including 42 patients with gastric cancer. The results showed peptic ulcer cases had elevated PG I and PG Ⅱ levels. The atrophic gastritis cases had low PG I levels and the gastric cancer cases had low PG I and low PG I/PG Ⅱ ratio. Using the cut off values of PG I<35μg/L and PG I/PG Ⅱ<1.5 for clinical purpose, the sensitivity and specificity of the test for gastric cancer was 73% and 78%, respectively. Combined with endoscope examination, the serum PG I and PG Ⅱ levels are valuable for the early diagnosis of gastric cancer.
关键词
胃癌
胃病
诊断
血液胃蛋白酶原
Pepsinogen, Radioimmunoassay, Gastric cancer, Early diagnosis
