5%NaHCO_3溶液漱口对胃内幽门螺杆菌的作用

Effect of 5%NaHCO_3 gargle on Helicobacter pylori inside stomach

目的寻找一种较为理想的防治胃内幽门螺杆菌 (Helicobacterpylori,Hp)的方法 ;方法将 2 0 0例胃H .pylori阳性患者随机分成A、B、C、D四组后接受抗H .pylori治疗 ,而B、C、D组分别应用 5 %NaHCO3溶液、4 %硼酸液、冷开水漱口 ,治疗后 1、6、12月分别对所有患者进行H .pylori检测并比较检测结果 ;结果四组胃内H .pylori阳性率分别为 34%、0、4 4 %、2 6 % ,差异有显著意义 (P <0 .0 1) ;结论 5 %NaHCO3溶液漱口对胃内幽门螺杆菌有明显的防治作用。

Objective This study was to evaluate the effect of different gargles in the long term treatment in eradication of Hel:cobacter pylori infection. Methods 200 patients with H.pylori positive were randomized into four groups(A?B?C and D group).Every group receive standardized anti H.pylori therapy.Moreover,B?C and D groups use different gargling agents(5%NaHCO 3 gargle,4% Boric acid gergle and cold boiled water)for 12 months respectively.We evaluate their effects from the rate of H.pylori positive inside stomach at different points(1?6?12 months during therapy).Result The rate of H.pylori positive was 34% for A group,0% for B group,44% for C group and 26% for d group. The rate of H.pylori positive in A group was significantly lower than in other groups( P <0.01).Conclusion Of the three gargles tested, using 5%NaHCO 3 gargle is helpful in eradication of H.pylori infection.