摘要
目的:探讨大鼠实验性胃溃疡自愈期间肾上腺髓质5-羟色胺(5-HT)免疫反应细胞的变化。方法:采用免疫组织化学方法(SP 法)显示5-HT 阳性细胞并用病理图像分析系统软件做面密度分析。结果:溃疡组5-HT 阳性细胞面密度于术后4d 增高(P<0.01),6d达高峰,与正常组相比差别显著(P<0.01);溃疡组5-HT 阳性细胞面密度于术后6d 高于盐水组(P<0.01)。结论:肾上腺髓质5-HT 阳性细胞可能间接或直接参与大鼠实验性胃溃疡修复的调节。
Objective:Studies on the changes of 5-HT immunoreactive cells in adrenal medulla of rats during the self-healing process of experimental gastric ulcer.Methods:The im- munohistochemical SP method was used to show 5-HT positive cells.The analysis software of pathological image was used in the Ssanalysis.Reasults:The morphometric results of 5-HT pos- itive cells of gastric ulcer group were more than the quantitation of the normal group on the 4th day after operation(P<0.01).The peak of the morphometric results of 5-HT positive cells ap- peared on the 6th day in experimental gastric ulcer group(P<0.01).The morphometric results of 5-HT positive cells in gastric ulcer group were more than the quantitation of the saline group on the 6th day after operation(P<0.01).Conclusion:The present work proved that the 5- HT cells of adrenal medulla were divedtly or indirectly participated on the regulation balance of endocrine during the self-healing process of the experimental gastric ulcer and here we provided morphological evidence.
