系统性红斑狼疮401例发病情况分析

Analysis of Clinical and Laboratory Manifestations of 401 Patients at the Onset of SLE

目的 探讨SLE的发病特点。方法 分析 40 1例SLE发病时临床表现及实验室检查 ,并进行不同性别与不同年龄间的比较。结果 关节痛的发生率最高 (88.66% ) ,其次为疲乏 (86.63 % )与脱发 (75 .0 7% ) ;男女患者关节痛的发生率差异有高度显著性 (χ2 =12 .918,P <0 .0 1) ;关节痛、失眠、心悸的程度在不同年龄组间差异有显著性。结论 SLE初期临床表现较复杂 ,但仍有一定的规律可循。

Objective To study the prevalence and characteristics of the main clinical and laboratory manifestations at the onset of SLE.Methods Analyze the clinical and laboratory manifestations of 401 cases at the onset of SLE,and test the differences and correlations related to sex and age.Results The most frequency initial manifestations were arthritis(88.66%),fatigue(86.63%) and alopecia(75.07%);a relative lower prevalence of arthritis were found in the male group than female one(χ 2= 12.918, P <0.01);significant differences were found in the prevalence of arthritis,insomnia and palpitation in relation to age.Conclusion Clinical and laboratory features of SLE are diversified,it makes precise diagnosis a real challenge for the clinician.Several differences have been observed in relation to the age of onset and the sex.