微核试验对东湖水中有机物遗传毒性的评价

Evaluation on Genotoxicity of Water and Tap Water of East Lake by Using Micronucleus Test

目的 了解武汉东湖水源水及自来水中非挥发性有机物遗传毒性状况。方法 采用小鼠骨髓嗜多染红细胞微核试验。结果 无论是自来水还是水源水均可不同程度地诱导小鼠骨髓细胞微核率升高 ,并且有剂量反应关系。平水期、丰水期的有机提取物细胞微核率高于枯水期。

Objective To determine the genotoxicity of non volatile organic compounds (NOCs) in raw and tap water of eset lake at Wuhan.Methods The NOCs in water were concentrated on XAD 2 resin and the genotoxicity of such compounds were examined by using mouse micronucleus text.Results The NOCs in raw and tap water could increases frequency of micronucleus in mouse bone marrow cells obviously and at the same time the dose response relation of them could be observed.Frequency of micronucleus caused by organic compounds is high in average and high period than that in low flow period.Conclusion The NOCs in water of various hydrographic could cause the genotoxicity for mouse bone marrow cells.