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慢性病流行病学研究的带时依变量多状态Cox回归模型 被引量:2

Multistate Cox Model with Time-dependent Covariates for Epidemiological Study on Chronic Diseases
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摘要 目的 探讨带时依变量多状态Cox回归模型在慢性病流行病学研究中的推广应用。方法 介绍带时依变量多状态Cox回归模型的基本原理 ,并将它应用于 2型糖尿病不同发展阶段影响因素的探讨。结果 应用带时依变量多状态Cox回归模型探讨 2型糖尿病不同发展阶段的影响因素 ,取得了较为满意的效果。 Objective To accelerate the generalization and application of multistate Cox model with time-dependent covariates during the epidemiological studies on chronic diseases.Methods Firstly introducing the basic principle of multistate Cox model with time-dependent covariates,and then applying to factors in influencing the various stages of type diabetes mellitus.Results The results gained by applying multistate Cox model with time-dependent covariates to study facotrs influencing the various stages of type 2 diabetes mellitus are satisfying.Conclusion Multistate Cox model with time-dependnet covariates is an avaliable tool during epidemiological study on chronic diseases.
出处 《中国公共卫生》 CAS CSCD 北大核心 2002年第11期1295-1297,共3页 Chinese Journal of Public Health
基金 四川大学华西医学中心博士基金资助
关键词 流行病学 带时依变量多状态Cox回归模型 2型糖尿病 慢性病 研究方法 multistate Cox regression model time-dependent covariate type 2 diabetes mellitus chronic disease
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  • 1Cox DR. Regression models and life- tables(with discussion). Journal of the Royal Statistical Society[J]. Set. B, 1972, 34(2): 187-202.
  • 2陈冠民,倪宗瓒,张菊英,王建琼,潘晓平.Ⅱ型糖尿病危险因素的多状态cox模型分析[J].数理医药学杂志,1998,11(2):97-99. 被引量:8
  • 3Lin DY. Cox regression analysis of multivariate failure time data:the marginal approach[J]. Statistics in Medicine, 1994, 13: 2233-2247.
  • 4Lin DY, Wei LJ. The robust inference for the Cox proportional hazards model [J]. Journal of the American Statistical Association,1989, 84:1074-1078.
  • 5Andersen PK. Multi - state models in survival analysis: a study of nephropathy and mortality in diabetes[J]. Statistics in Medicine,1988, 7: 661-670.

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