嗅鞘细胞生物学特性及其在脊髓再生中应用的研究

Biological Characterizations and Application of Olfactory Ensheathing Cells in Regeneration of Spinal Cord

近年来研究证明嗅球及嗅神经组织可以分离出嗅神经鞘细胞 (olfactory ensheathingcells,OECs) ,OECs具有中枢神经系统 (CNS)星形胶质细胞和外周雪旺式细胞的特性 ,移植后的 OCEs能够在宿主损伤的脊髓组织进行迁移 ,能够引导支持损伤的神经元突起再生、生长、延伸。而且还可以通过转基因技术使其携带某些促进神经元再生的外源性基因 ,表达一些促神经再生的分子 ,从而改善神经损伤的内环境 ,诱导损伤的脊髓神经元再生 ,使得受损脊髓再生的潜力得以发挥 ,达到脊髓再生和功能恢复的目的。本文就

Recent studies have revealed that Olfactory ensheathing cells (OECs) are distributed within Olfactory ensheathing bulbs,Olfactory epithelium and Olfactory nerve. The cell can exhibit phenotypic and functional properties known to both Schwan cell in peripheral nervous system and astrocyte in central nervous system.When OECs were transplanted into injured areas of spinal cord ,these cells are able to survive and migrate in the injured location.Furthermore, The injured neuronal axonal regeneration,neurite growth and elongation are supported and guided with accompanying OECs migration. In addtion, Transgenic technological application might be undertaken to develop OECs carrying exgenous genes,which mediate neuronal regeneration in Spinal cord. With expression of these molecules,The appropriate environment for injured areas of nervous regeneration was created, and The potential of spinal cord regeneration manifested and the purpose of spinal cord funcational recovery would be achieved.In this article,The OECs biological properties,its application in spinal cord injury and genic therapy in CNS are reviewed.